COX-2 inhibitor

COX-2 inhibitor
any one of a group of anti-inflammatory drugs (see NSAID) that selectively block the action of the enzyme cyclo-oxygenase 2 (COX-2), which mediates the production of prostaglandin at sites of inflammation, especially in joints; they are less likely to inhibit COX-1, which controls the production of prostaglandin in the stomach (where it is involved in the production of protective mucus), and therefore less likely than nonselective NSAIDs to cause peptic bleeding or ulceration. COX-2 inhibitors are used in the treatment of arthritis, acute gout, and moderate or severe pain. They include celecoxib, etoricoxib (Arcoxia), and lumiracoxib (Prexige). However, because their use is associated with an increased incidence of heart attack and stroke, COX-2 inhibitors should be taken only by those who are not at risk of developing these conditions and who have a high risk of developing peptic ulceration. Other side-effects include fluid retention (oedema), intestinal upset, dizziness, insomnia, and sore throat.

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  • COX-2 inhibitor — COX 2 selective inhibitor is a form of non steroidal anti inflammatory drug (NSAID) that directly targets COX 2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX 2 reduces the risk of peptic ulceration, and is the… …   Wikipedia

  • COX-2-Inhibitor — Als COX 2 Hemmer oder auch COX 2 Inhibitor bezeichnet man eine Gruppe von entzündungshemmenden Arzneistoffen, bei der nur eine der Unterformen der Cyclooxygenase (COX) gehemmt wird. Die wichtigsten Unterformen dieses Enzyms sind die… …   Deutsch Wikipedia

  • Cox-2 inhibitor — A class of drugs that selectively blocks a specific enzyme called Cox 2. Blocking this enzyme impedes the production of the chemical messengers that cause the pain and swelling of arthritis inflammation. Cyclooxygenase 1 (Cox 1) is an enzyme… …   Medical dictionary

  • COX-2 inhibitor — Cyclo oxygenase 2 inhibitor. A nonsteroidal anti inflammatory drug used to relieve pain and inflammation. COX 2 inhibitors are being studied in the prevention of colon polyps, and as anticancer drugs. Also called cyclo oxygenase 2 inhibitor …   English dictionary of cancer terms

  • Cox-2 inhibitor — noun an anti inflammatory drug that fights pain and blocks Cox 2 activity without impeding the activity of Cox 1; increases the risk of heart attacks Cox 2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys •… …   Useful english dictionary

  • COX-2 inhibitor — noun Date: 1994 any of a class of drugs used to treat the pain and inflammation of arthritis by selectively blocking the variant of cyclooxygenase causing these symptoms …   New Collegiate Dictionary

  • Cyclooxygenase-2 (Cox-2) inhibitor — A class of drugs that selectively blocks a specific enzyme called Cox 2. Blocking this enzyme impedes the production of the chemical messengers that cause the pain and swelling of arthritis inflammation. Cyclooxygenase 1 (Cox 1) is an enzyme… …   Medical dictionary

  • COX-2 — käks tü n 1) the isoform of cyclooxygenase that is expressed esp. in the brain and kidneys and at sites of inflammation 2) COX 2 INHIBITOR …   Medical dictionary

  • COX-2-Hemmer — Als COX 2 Hemmer oder auch COX 2 Inhibitor bezeichnet man eine Gruppe von entzündungshemmenden Arzneistoffen, bei der nur eine der Unterformen der Cyclooxygenase (COX) gehemmt wird. Die wichtigsten Unterformen dieses Enzyms sind die… …   Deutsch Wikipedia

  • COX-3 — Cyclo oxygenase 3 Enzyme Two cyclooxygenase isozymes, COX 1 and COX 2, are known to convert arachidonic acid into prostaglandins and are the targets of nonsteroidal anti inflammatory drugs (NSAIDs). A third distinct COX isozyme, COX 3, as well as …   Wikipedia

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